Akụrụngwa Neural Lee U
Akwụkwọ nka zuru oke na prosthesis cortical visual, gụnyere nkọwa ngwaike, ụkpụrụ mkpali, nhazi usoro, na ndetu mmejuputa.
1. Usanifu wa mfumo
1.1 Nchịkọta
Sistemụ ntinye akwara See U bụ isi ihe atọ na-arụkọ ọrụ ọnụ iji weghara, hazie, na zipu ozi anya ozugbo na cortex bụ isi nke onye ọrụ.
Akụkụ mpụga
- • Igwefoto CMOS (16MP)
- • Ngalaba nhazi
- • Batrị mpụga (2500mAh)
- • RF nnyefe
Akụkụ subcutaneous
- • RF nnata
- • Ihe nrụpụta mgbaàmà
- • Batrị enweghị ike ịkụnye
- • Electrode njikwa
Akụkụ intracortical
- • 1024-electrode n'usoro
- • Mkpụrụ na-agbanwe agbanwe
- • Kiolesura cha Neural
- • Ihe mmetụta impedance
1.2 Data eruba
Edede onyonyo
Igwefoto CMOS na-ese foto 60 FPS na 1920x1080. Ihe mmetụta uche dị elu (ruo ISO 6400) na-akwado ọrụ obere ọkụ.
Na-ebu ụzọ nhazi
Algọridim n'ọhụụ Kọmputa na-etinye nchọpụta ihu, ọdịiche na-agbanwe agbanwe, na mbelata mkpọtụ. E wedara onyonyo a ka ọ bụrụ maapụ 32x32 ka ọ na-edobe ozi dị oke mkpa.
Maapụ retinotopic
Edebere nhazi onyonyo gbasara ohere ka ọ bụrụ ọnọdụ kwekọrọ na cortex anya, na-eso nzukọ retinotopic eke V1.
Ndokwa ihe mkpali
A na-emepụta ụkpụrụ pulse eletrik site na nhazi kachasị mma (njupụta, ugboro, ogologo oge) maka electrode ọ bụla dabere na ike pikselụ kwekọrọ.
nnyefe RF
A na-eziga data etinyere ihe karịrị 13.56 MHz RF site na akpụkpọ ahụ gaa na nnata nke subcutaneous, yana nkwụsị njedebe na njedebe n'okpuru 50 ms.
Mkpali akwara
Onye na-ahụ maka eletrọd na-etinye pulses biphasic na microelectrodes, na-anya neurons kpọmkwem yana phosphenes nke onye ọrụ ghọtara.
2. Akụrụngwa nkọwa
2.1 Mpụga unit
Igwefoto
Ihe nhazi
Ike
2.2 Nke a na-akụnye ya
RF nnata
Ihe nrụpụta mgbaàmà
Batrị enweghị ike ịkụnye
Akụkụ anụ ahụ
3. Microelectrode n'usoro
3.1 Nkọwapụta elektrọn
Akụkụ geometric
Akụrụngwa na mkpuchi
3.2 Njirimara eletrik
Mkpali
Nchekwa
nlekota oru
3.3 Utangamano wa kibayolojia
Nzaghachi anụ ahụ
PEDOT: mkpuchi PSS na-ebelata mbufụt na ọnya glial. Nnyocha na-egosi impedance kwụsiri ike maka ihe karịrị afọ 2 na vivo.
Mechanical mgbanwe
Polyimide na-agbanwe agbanwe (modules nke ntorobịa ~ 2.5 GPa) na-ebelata nchekasị na anụ ahụ cortical (~ 1 kPa), na-ebelata micro-trauma site na mmegharị ụbụrụ.
Sterilisation
Ethylene oxide (EtO) na-echekwa ihe na akụrụngwa eletrik, kwadoro na ISO 11135.
4. Nhazi mgbaàmà
4.1 Nhazi pipeline
Kwụpụ 1: Mepụta na nhazi
- • Were: Oghere RGB 1920 × 1080 @ 60 FPS
- • Ntughari: RGB → isi awọ (luminance ịdị arọ)
- • Nhata: Histogram Adaptive (CLAH) maka ọdịiche
- • Na-ajụ: Ihe nzacha abụọ na-echekwa ọnụ
- • Kuchelewa: <5 ms
Nzọụkwụ 2: Mwepụta atụmatụ
- • Nchọpụta ihu: Ọtụtụ ihe nzacha Sobel
- • Utulivu: Maapụ nlebara anya anya dabere na ọdịiche
- • Nkebi: Ọnụ ọgụgụ-ala nwere ọnụ ụzọ ngbanwe
- • Ibu ụzọ: Ihe na-akpụ akpụ na-ebuwanye ibu
- • Kuchelewa: <8ms
Nzọụkwụ 3: Smart downsampling
- • Mkpebi ebumnuche: 32x32 pikselụ (isi 1024)
- • Usoro: Ịkọkọ ọnụ na-agbanwe agbanwe na-edobe ozi dị oke mkpa
- • Ịdị arọ: Mpaghara etiti na-enweta mkpebi dị irè karị
- • Ubungakanani: 8 ọkwa ike kwa pikselụ
- • Kuchelewa: <3ms
Nzọụkwụ 4: Retinotopic maping
- • Gbanwee: Cartesian → nchịkọta log-polar
- • Mbuli elu cortical: Njupụta etiti dị elu (fovea)
- • nhazi nhazi: Ndozigharị kwa onye ọrụ
- • Nkwụghachi ụgwọ: Mgbagwoju okirikiri cortical
- • Kuchelewa: <2ms
Kwụpụ 5: Ndozi ihe mkpali
- • Maapụ: Pixel ike → pulse parameters
- • Mgbanwe: Njupụta na/ma ọ bụ ugboro ugboro
- • Nhazi oge: Mmekọrịta nke ọwa 1024 niile
- • Nkwalite: Algọridim mmụta ngbanwe
- • Kuchelewa: <2ms
⚡ Latency pipeline nke ngwụcha ruo na ngwụcha: <20ms (site na ijide ruo na mkpali)
4.2 Algọridim kachasị mma
mmụta ngbanwe
Usoro a na-eji mmụta igwe na-emegharị mkpali sitere na nzaghachi onye ọrụ na metrik arụmọrụ.
- • Akpaaka kwa-electrode njupụta
- • Ntugharị nghọta dị iche
- • Nkwụghachi ụgwọ mbugharị impedance
- • Maapụ retinotopic ahaziri onwe ya
Amụma ngagharị
Ntugharị anya na amụma oge na-egbutu aghọtala echere ma melite nghọta ihe na-agagharị agagharị.
- • Atụmatụ ọsọ na ntụzịaka
- • Extrapolation ọnọdụ n'ọdịnihu
- • Kulainisha trajectory
- • Ihe dị mkpa maka ihe na-akpụ akpụ
5. Nzikọrịta ozi
5.1 data telemetry
Nkọwapụta RF
Usoro nzikọrịta ozi
5.2 Nchekwa njikọ
Izo ya ezo
AES-128 maka data ozugbo. Igodo otu-ngwaọrụ emebere na njikọta mbụ. Ntụgharị igodo nnọkọ kwa awa 24 ọ bụla.
Nyocha
Ihe ịma aka n'otu n'otu - nzaghachi n'etiti nkeji mpụta na ịkụnye, na-egbochi imegharị ya na mbupụ. Oge ngwụcha nke nnọkọ ka nkeji ise gachara.
Nchedo nnyonye anya
FHSS gafere ọwa 50, njikwa nkukota akpaka, yana ọnọdụ ọdịda maka gburugburu mkpọtụ RF dị elu.
6. Njikwa ike
6.1 Nchaji inductive
Ụkpụrụ ọrụ
Njikọ inductive resonant na 13.56 MHz na-ebufe ike site na akpụkpọ ahụ na-enweghị njikọ ọ bụla.
- • Nyefee eriri igwe: Dayameta 50 mm, ntụgharị 10
- • Nata eriri igwe: Dayameta 35 mm, ntụgharị 15
- • arụmọrụ: 60-70% na oghere 5 mm
- • Enyere ike: 500mW ụdị, 1W max
- • Nhazi: ± 10 mm ndidi n'akụkụ
sekit njikwa
PMIC raara onwe ya nye na-achịkwa ịchaji na ịfesa ike na sistemụ akụrụngwa niile.
- • Ndozi: Schottky akwa
- • Iwu: Ibhanti 3.6V → 1.8V/3.3V
- • Nchaji: CC/CV nwere nkwụsị akpaka
- • Nchedo: Ịgabiga oke, oke ọkụ, okpomọkụ
- • nlekota oru: Coulomb counter maka steeti ụgwọ
6.2 nkwalite ike
Ike mmefu ego nkewa
(60mW)
(45mW)
(30mW)
(15mW)
Ụdị ọrụ
Ihe mkpali 60 FPS na-aga n'ihu, sistemụ mpaghara niile na-agbanye.
30 FPS, nhazi ọkụ ọkụ, ndụ batrị ogologo.
Gbanyụọ mkpali; RF na nlekota oru na; ngwa ngwa teta.
Opekempe: elekere na chaja chọpụta naanị; ọnwa nke ndụ.
7. Safety na biocompatibility
7.1 Ụkpụrụ na asambodo
Utangamano wa kibayolojia
- ISO 10993: Nyocha ndu nke ngwaọrụ ahụike
- USP Klas VI: Nyocha cytotoxicity
- I-ASTM F756: Ihe ndị a na-akụnye
Nchekwa eletriki
- I-IEC 60601-1: Nchekwa akụrụngwa ahụike
- I-IEC 60601-2-40: Ndị neurostimulators
- IEEE C95.1: Oke mkpughe RF
7.2 Usoro nchekwa
Nchekwa ngwaike
- • Oke ugbu a: Nrube isi netwọk mmepụta na 200μA
- • Chọpụta obere okirikiri: Mwepu akpaaka na <1ms
- • Okpomọkụ: Mkpuchi okpomọkụ na 41ºC
- • Onye nche: Tọgharịa na kpọgidere firmware
- • Ihe nchekwa ike: Capacitor maka nkwụsị a na-achịkwa
Nchekwa ngwanrọ
- • Iguzosi ike n'ezi ihe: CRC na firmware na paramita
- • Oke mkpali: Nkwado na mgbanwe ọ bụla
- • Ndekọ mmemme: Mmejọ na akụkọ ihe mere eme
- • Ọnọdụ nchekwa: Ihe ndabara nke mgbanwe
- • Mmelite OTA: Chekwaa ya na nlọghachi azụ
nlekota na-aga n'ihu
- • Elektroni Z: A na-enyocha kwa 100ms
- • Tinye okpomọkụ: Ihe mmetụta anọ kesara
- • Batrị: Live SOC na SOH
- • RF njikọ: RSSI na ọnụego mperi
- • Ụgwọ ịgba ọgwụ: Ihe nchikota kwa-electrode
7.3 Nnwale nchekwa
Katika vitro
- • Omenala sel akwara
- • I-Cytotoxicity
- • Kutu
- • Mechanical ike ọgwụgwụ
- • Nkọwapụta ọkụ eletrik
Na vivo
- • Ụdị anụmanụ
- • Nzaghachi anụ ahụ
- • Nnwale arụrụ arụ
- • Nleba anya ogologo oge
- • Histolojia
Kliniki
- • Enwere ike ime
- • Nnwale nchekwa
- • Ịrụ ọrụ
- • Nleba anya ogologo oge
- • Ihe ọjọọ
8. Usoro mkpali
8.1 Akụkụ mkpali
Umbo la wimbi
Mgbagwoju anya biphasic Symmetric: akụkụ cathodic nke mbụ, emesia anodic. 50 μs inter-pulse oghere maka mwepu capacitive. <1% na-akwụ ụgwọ ahaghị nhata ka ịzenarị nrụpụta electrochemical.
Oge nke Cathodic (na-akpali akpali).
- • Ngosipụta: 10-200 μA (nwere ike idozi)
- • Ogologo oge: 100-500 μs
- • Polarity: adịghị mma
- • Ụdị: Rectangular
Anodic (nnaghachi) agba
- • Njupụta: dakọtara cathodic
- • Ogologo oge: dakọtara cathodic
- • Polarity: Ọ dị mma
- • Ụdị: Rectangular
Achọpụtara njikwa ike
A na-agbanwe ike phosphene n'ụzọ atọ agbakwunyere:
Ihe dị ugbu a 10-200 μA; ihe dị ka logarithmic nwere nchapụta ahụrụ. Ọkwa asatọ pụrụ iche maka arụmọrụ.
Ọnụọgụ mkpụrụ akụ 50-300 Hz; ọnụ ọgụgụ dị elu na-agụ nke ọma, bara uru maka njikwa dị mma na-enweghị iweghachite ugbu a.
100-500 μs; ogologo pulses na-agbanyekwu ụgwọ ma yie ka ọ na-egbuke egbuke, nke nchekwa electrochemistry jikọtara ya.
8.2 Usoro ntinye koodu
Koodu oghere
Maapụ kpọmkwem site na pikselụ onyonyo ọ bụla gaa n'usoro elektrọd ya, dabara na nhazi cortical retinotopic.
- • Mkpebi: 32x32 → elektroni 1024
- • Mbuli elu cortical: Okpokoro etiti
- • Gbanwee: Log-polar fovea nlereanya
- • nhazi nhazi: Ndozigharị kwa onye ọrụ
Koodu nwa oge
Oge mkpali na-egosi karịa ike - mmegharị, omimi, na salience.
- • fesa: Ụgbọ oloko maka ịkwaga ihe
- • Mmekọrịta: Usoro dị n'ofe saịtị
- • Usoro oge: Koodu ederede
- • Ọnụego mgbanwe: Ọnụọgụ egwu dị iche
8.3 Nbulite na nhazi nkeonwe
Nhazi mbido
Izu abụọ ma ọ bụ anọ iji tọọ ọnụ ụzọ na ebe ọrụ nchekwa dị n'otu saịtị:
- Ọnụ ụzọ nghọta (10-50 μA na-ahụkarị)
- Oke nkasi obi (100-150 μA na-ahụkarị)
- Maapụ retinotopic omenala
- Ndozi ngalaba oge (ọnụego, obosara)
- Nnwale ụkpụrụ dị mfe
Mgbanwe na-aga n'ihu
Usoro a na-amụta ka oge na-aga site na:
- • Ntinye onye ọrụ: Nchapụta/ọdịiche nke aka
- • Ihe ịga nke ọma ọrụ: Ọnụọgụ igodo na njirimara
- • Z ịkpafu: Ndozi akpaaka
- • Jiri ụkpụrụ: Ndozi ihe nkiri ugboro ugboro
- • Plastiki ya Neural: Ndozigharị ogologo oge
Ụdịdị pụrụ iche
Profaịlụ arụgoro mbụ maka ojiji a na-ejikarị:
Ọdịiche dị elu, ngagharị dị ala
Motion, omimi, na ihe mgbochi
Ihu, ihe, na akara ngosi
Nweta na mgbanwe iche