Kwimura Neural Reba U.
Inyandiko yuzuye ya tekiniki kuri prothèse igaragara, harimo ibyuma bisobanurwa, protocole yo gukangura, sisitemu yububiko, hamwe nibisobanuro byashyizwe mubikorwa.
1. Sisitemu yububiko
1.1 Incamake
Reba U neural implant sisitemu igizwe nibice bitatu byingenzi bikorana kugirango ifate, itunganyirize, kandi yohereze amakuru yibonekeje kumurongo wambere wibanze ukoresha.
Ibigize hanze
- • Kamera ya CMOS (16MP)
- • Igice cyo gutunganya
- • Bateri yo hanze (2500mAh)
- • Ikwirakwiza rya RF
Ibice byubutaka
- • Ikirangantego cya RF
- • Ikimenyetso
- • Bateri ishobora kwimurwa
- • Umugenzuzi wa electrode
Ibice bidasanzwe
- • 1024-amashanyarazi
- • Imiterere ihindagurika
- • Imigaragarire
- • Rukuruzi
1.2 Amakuru atemba
Gufata amashusho
Kamera ya CMOS ifata ama frame 60 ya FPS kuri 1920x1080. Rukuruzi rwinshi-rugera kuri ISO 6400) rushyigikira imikorere-yoroheje.
Gutunganya
Mudasobwa-iyerekwa rya algorithms ikoresha impande zerekana, itandukaniro rihindagurika, no kugabanya urusaku. Ishusho yamanuwe ku ikarita ya 32x32 mugihe ubika amakuru akomeye.
Ikarita ya Retinotopic
Umwanya uhuza amashusho uhuza imyanya ijyanye na cortex igaragara, ukurikije ishyirahamwe risanzwe rya V1 retinotopic.
Kode ya Stimulus
Amashanyarazi yimashanyarazi yakozwe hamwe nibintu byiza (amplitude, frequency, igihe) kuri buri electrode ishingiye kuri pigiseli ihuye.
Ikwirakwizwa rya RF
Encoded data yoherejwe hejuru ya 13.56 MHz RF binyuze muruhu kubakira munsi yubutaka, hamwe nubukererwe bwanyuma-bwanyuma munsi ya ms 50.
Kubyutsa imitsi
Umugenzuzi wa electrode akoresha biphasic pulses kuri microelectrode, gutwara neuron yihariye no gutanga fosifene yabonwa numukoresha.
2. Ibisobanuro byibyuma
2.1 Igice cyo hanze
Kamera
Umushinga
Imbaraga
2.2 Igice cyimurwa
Ikirangantego cya RF
Ikimenyetso
Bateri ishobora kwimurwa
Ibipimo bifatika
3. Safu ya Microelectrode
3.1 Ibisobanuro bya electrode
Ibipimo bya geometrike
Ibikoresho hamwe
3.2 Ibiranga amashanyarazi
Kubyutsa
Umutekano
Gukurikirana
3.3 Ibinyabuzima
Igisubizo
PEDOT: Ipfunyika rya PSS rigabanya gucana no gukomeretsa glial. Ubushakashatsi bwerekana inzitizi zihamye kumyaka irenga 2 muri vivo.
Guhindura imashini
Flexible polyimide (Modulus yumusore ~ 2.5 GPa) igabanya imihangayiko kumitsi ya cortical (~ 1 kPa), igabanya ihahamuka rito rituruka kumikorere yubwonko.
Kurimbuka
Ethylene oxyde (EtO) ibika ibikoresho nibikoresho byamashanyarazi, byemewe na ISO 11135.
4. Gutunganya ibimenyetso
4.1 Gutunganya umuyoboro
Intambwe ya 1: Gufata no gutunganya mbere
- • Gufata: Amakadiri ya RGB 1920x1080 @ 60 FPS
- • Guhindura: RGB → ibara ryinshi (uburemere bwa luminance)
- • Kuringaniza: Guhindura amateka ya porogaramu (CLAHE) kugirango itandukanye
- • Kwanga: Akayunguruzo kombi kurinda impande
- • Ubukererwe: <5 ms
Intambwe ya 2: Gukuramo ibintu
- • Kumenya impande: Ingano-nini ya Sobel muyunguruzi
- • Icyubahiro: Ikarita ishingiye ku ikarita yerekana ibitekerezo
- • Igice: Igishushanyo –ubutaka hamwe nimbibi zijyanye no guhuza n'imiterere
- • Ibyingenzi: Kwimura ibintu bigira uburemere buke
- • Ubukererwe: <8ms
Intambwe ya 3: Kumanura ubwenge
- • Gukemura intego: 32x32 pigiseli (amanota 1024)
- • Uburyo: Guhuza imihindagurikire y'ikirere kubika amakuru akomeye
- • Ibiro: Uturere two hagati tubona igisubizo cyiza
- • Umubare: Urwego 8 rwimbaraga kuri pigiseli
- • Ubukererwe: <3ms
Intambwe ya 4: Ikarita ya retinotopic
- • Hindura: Cartesian → log-polar ikora
- • Gukuza Cortical: Ubucucike buri hagati (fovea)
- • Urekebishaji: Kuringaniza umukoresha
- • Indishyi: Cortical curvature kugoreka
- • Ubukererwe: <2ms
Intambwe ya 5: Kode ya Stimulus
- • Ikarita: Pixel ubukana → ibipimo bya pulse
- • Guhindura: Pulse amplitude na / cyangwa inshuro
- • Igihe: Guhuza imiyoboro yose 1024
- • Gukoresha neza: Kwiga imiterere ya algorithm
- • Ubukererwe: <2ms
Umuyoboro utangirira ku ndunduro: <20ms (kuva gufata kugeza kubyutsa)
4.2 Gukoresha algorithms
Kwiga kumenyera
Sisitemu ikoresha imashini yiga kugirango ihuze ibitera imbaraga kubitekerezo byabakoresha nibipimo byerekana.
- • Kiotomatiki kwa elektrodi amplitude
- • Kuringaniza itandukaniro
- • Impedance drift indishyi
- • Ikarita yihariye ya retinotopic
Guhanura icyerekezo
Gutembera neza hamwe no guhanura by'agateganyo kugabanya gutinda no kunoza ibintu-bigenda.
- • Ikigereranyo cyihuta nicyerekezo
- • Umwanya uzaza hanze
- • Inzira yoroshye
- • Ibyingenzi kubintu byimuka
5. Itumanaho
5.1
Ibisobanuro bya RF
Porotokole y'itumanaho
5.2 Huza umutekano
Usimbaji fiche
AES-128 kumakuru nyayo. Urufunguzo rwibikoresho byose byakozwe muburyo bwa mbere. Isomo urufunguzo ruzunguruka buri masaha 24.
Kwemeza
Ikibazo hagati - igisubizo hagati yikigo cyo hanze no gushiramo, guhagarika gusubiramo no gushimuta. Igihe cyamasomo nyuma yiminota 5 idakora.
Kurinda kwivanga
FHSS mumiyoboro 50, kugongana byikora, hamwe nuburyo bwo gusubira inyuma urusaku rwinshi rwa RF.
6. Gucunga ingufu
6.1 Kwishyuza
Ihame ry'imikorere
Ihuza rya resonant inductive kuri 13.56 MHz ihererekanya imbaraga binyuze muruhu rudafite aho ruhurira.
- • Kohereza igiceri: Dimetero 50 mm, imirongo 10
- • Akira igiceri: Diameter ya mm 35, imirongo 15
- • Gukora neza: 60-70% kuri 5 mm icyuho
- • Imbaraga zatanzwe: 500 mW isanzwe, 1 W max
- • Guhuza: Mm 10 mm kwihanganira kuruhande
Inzira yo kuyobora
PMIC yihariye igenga kwishyuza no gukoresha ingufu kuri sisitemu zose zatewe.
- • Gukosora: Ikiraro cya Schottky
- • Amabwiriza: Amafaranga 3.6V → 1.8V / 3.3V
- • Kwishyuza: CC / CV hamwe no guhagarika byikora
- • Kurinda: Birenze urugero, birenze urugero, ubushyuhe
- • Gukurikirana: Coulomb compte ya leta ishinzwe
6.2 Gukoresha ingufu
Ingengo yimari yingufu
(60mW)
(45mW)
(30mW)
(15mW)
Uburyo bukoreshwa
Gukomeza 60 FPS itera imbaraga, sisitemu zose kuri.
30 FPS, gutunganya byoroheje, igihe kirekire cya bateri.
Kubyutsa; RF no gukurikirana kuri; kanguka vuba.
Ntarengwa: isaha n'amafaranga byerekana gusa; amezi y'ubuzima.
7. Umutekano hamwe na biocompatibilité
7.1 Ibipimo n'impamyabumenyi
Ibinyabuzima
- ISO 10993: Isuzuma ryibinyabuzima ryibikoresho byubuvuzi
- USP Icyiciro cya VI: Kwipimisha Cytotoxicity
- I-ASTM F756: Ibikoresho byimurwa
Umutekano w'amashanyarazi
- I-IEC 60601-1: Umutekano wibikoresho byubuvuzi
- I-IEC 60601-2-40: Neurostimulator
- IEEE C95.1: Imipaka ntarengwa ya RF
7.2 Uburyo bwumutekano
Kurinda ibyuma
- • Imipaka igezweho: Umuyoboro wujuje ibisabwa usohoka kuri 200μA
- • Ikimenyetso kigufi: Gukata byikora muri <1ms
- • Ubushyuhe: Guhagarika ubushyuhe kuri 41 ° C.
- • Indorerezi: Ongera usubire kumashanyarazi
- • Ingufu zingufu: Ubushobozi bwo guhagarika ibikorwa
Kurinda software
- • Ubunyangamugayo: CRC kuri software hamwe nibipimo
- • Imipaka ntarengwa: Kwemeza kuri buri mpinduka
- • Ikirangantego: Amateka namateka adasanzwe
- • Uburyo butekanye: Ibisanzwe
- • Ibishya bya OTA: Umutekano hamwe no gusubira inyuma
Gukomeza gukurikirana
- • Electrode Z.: Icyitegererezo buri 100m
- • Kwimura temp: Ibyuma bine byakwirakwijwe
- • Batteri: Kubaho SOC na SOH
- • Ihuza rya RF: Igipimo cya RSSI n'ikosa
- • Amafaranga yatewe: Imashini ya electrode
7.3 Ikizamini cyumutekano
Muri vitro
- • Umuco w'akagari
- • I-Cytotoxicity
- • Ruswa
- • Umunaniro wa mashini
- • Ibiranga amashanyarazi
Muri vivo
- • Icyitegererezo cy'inyamaswa
- • Igisubizo
- • Ibizamini bikora
- • Gukurikirana igihe kirekire
- • Amateka
Ivuriro
- • Ibishoboka
- • Ibigeragezo byumutekano
- • Ingaruka
- • Gukurikirana igihe kirekire
- • Ibintu bibi
8. Porotokole yo gukangura
8.1 Ibipimo byo gukangura
Umuhengeri
Symmetric biphasic pulses: icyiciro cya cathodic mbere, hanyuma anodic. 50 μs intera-pulse icyuho cyo gusohora ubushobozi. <1% yishyuza ubusumbane kugirango wirinde kubaka amashanyarazi.
Icyiciro cya Cathodic (gitera imbaraga)
- • Amplitude: 10–200 μA (birashoboka)
- • Igihe rimara: 100-500 μs
- • Ubuharike: Ibibi
- • Imiterere: Urukiramende
Icyiciro cya Anodic (kugarura)
- • Amplitude: Ihuza cathodic
- • Igihe rimara: Ihuza catodiki
- • Ubuharike: Ibyiza
- • Imiterere: Urukiramende
Kugaragara kugenzura imbaraga
Imbaraga za fosifeni zahinduwe muburyo butatu bwuzuzanya:
Urwego rugezweho 10–200 μA; hafi ya logarithmic hamwe numucyo ugaragara. Inzego umunani zidasanzwe kugirango zikore neza.
Igipimo cya pulse 50–300 Hz; ibiciro biri hejuru soma neza, bifite akamaro kugenzura neza utagarutse kurubu.
100-500 μs; impiswi ndende itera inshinge nyinshi kandi igaragara neza, igarukira kumutekano wa electrochemie.
8.2
Kode y'ahantu
Ikarita itaziguye kuri buri shusho pigiseli kuri array electrode yayo, ihujwe na retinotopic cortical layout.
- • Umwanzuro: 32x32 → 1024 electrode
- • Gukuza Cortical: Hagati
- • Hindura: Moderi yerekana inkingi
- • Urekebishaji: Kuringaniza umukoresha
Kode y'agateganyo
Igihe cyo gukangura kirimo ibirenze ubukana - icyerekezo, ubujyakuzimu, na salience.
- • Guturika: Gariyamoshi yo kwimura ibintu
- • Guhuza: Icyiciro gifitanye isano kurubuga
- • Uburyo bwigihe: Kode y'imyenda
- • Igipimo cyo kurwanya imihindagurikire y'ikirere: Ikigereranyo cyerekana itandukaniro
8.3 Gukwirakwiza no kwimenyekanisha
Ihinduka rya mbere
Ibyumweru bibiri cyangwa bine kugirango ushireho imipaka hamwe nibikorwa bikora neza kurubuga:
- Ibipimo byerekana (10-50 μA bisanzwe)
- Urwego rwo guhumuriza (100–150 μA bisanzwe)
- Ikarita ya retinotopic
- Guhuza igihe-indangarugero (igipimo, ubugari)
- Ibizamini byoroshye
Guhuza n'imihindagurikire y'ikirere
Sisitemu yiga mugihe kuva:
- • Umukoresha: Kumurika intoki / itandukaniro
- • Intsinzi: Kugenda no kumenya amanota
- • Z ukukhukhuleka: Gukosora imodoka
- • Koresha imiterere: Kuringaniza-kenshi
- • Amashanyarazi: Gusubiramo igihe kirekire
Uburyo bwihariye
Imyirondoro yabanjirije kubakoresha bisanzwe:
Itandukaniro rinini cyane, kugenda hasi
Icyerekezo, ubujyakuzimu, n'inzitizi
Isura, ibintu, nibimenyetso byerekana
Kwunguka no guhuza n'imiterere